sirtuins
14 episodes mention this concept
hubermanlabOct 30, 2025The Biology of Slowing & Reversing Aging: Epigenetics, Fasting, and Longevity with Dr. David Sinclair
HealthLongevityAnti-agingAging as a diseaseEpigenome- hubermanlabAug 28, 2025
The Science of Intermittent Fasting & Time-Restricted Eating: Mechanisms, Protocols, and Health Benefits
HealthIntermittent Fasting (IF)Time-Restricted Feeding (TRF)Calories In, Calories Out (CICO)Basal Metabolic Rate (BMR) 
drekbergFeb 9, 2024What Happens During a 100-Hour Fast: Unlocking Metabolic Health and Longevity
HealthExtended FastingIntermittent FastingAutophagyInsulin Sensitivity- drekbergAug 11, 2023
The Metabolic Impact of a 100-Hour Fast: Blood Work Analysis, Autophagy, and Practical Protocols
HealthAutophagyGlucose Ketone Index (GKI)Nutritional KetosisInsulin Resistance - drekbergJun 23, 2023
Metabolic Preparation for Fasting: Achieving Fat Adaptation and Electrolyte Balance
HealthFastingIntermittent FastingMetabolic FlexibilityFat Adaptation - drekbergJun 2, 2023
The Secret to Comfortable Extended Fasting: Electrolyte Balance for Autophagy and Health Benefits
HealthExtended FastingIntermittent FastingAutophagyInsulin Resistance - drekbergJan 13, 2023
Activating Autophagy for Longevity: The Science of Exercise and Fasting for Optimal Health
HealthAutophagyHypoxiaMisfolded proteinsProtein aggregates - hubermanlabDec 27, 2021
The Biology of Slowing & Reversing Aging: Epigenetics, Fasting, and Longevity Interventions with Dr. David Sinclair
ScienceAging as a diseaseEpigenomeSirtuinsLongevity genes - drekbergJul 30, 2021
Challenging Age-Related Decline: Epigenetics, Personal Control, and the Dynamic Body
HealthArterial stiffeningHypertensionBone lossOsteoporosis - drekbergJul 23, 2021
The Physiological Impact of Fasting: From 12 Hours to 5 Days and Its Profound Health Benefits
HealthGlycogen depletionKetonesKetoacidosisMetabolic flexibility 
lexfridmanJun 7, 2021The Information Theory of Aging, Bio-Wearables, and the Future of Human Longevity with David Sinclair
ScienceLongevity researchInformation theory of agingEpigenomeGenome- drekbergDec 18, 2020
The Physiological Mechanisms and Adaptive Benefits of Wim Hof Breathing and Cold Therapy
HealthWim Hof MethodAutonomic Nervous System (ANS)Sympathetic Nervous System (SNS)Parasympathetic Nervous System (PNS) - drekbergJul 3, 2020
Aging in Reverse: Reconceptualizing Aging as a Disease and Leveraging Epigenetic Control for Longevity
HealthAging as a diseaseLoss of information theory of agingGenetic informationEpigenetic information - hubermanlab
Longevity Interventions: A Deep Dive into NAD, Rapamycin, and Dr. Peter Attia's Healthspan Strategies
HealthNAD pathwayNicotinamide Riboside (NR)Nicotinamide Mononucleotide (NMN)Healthspan
Knowledge Graph
Related concepts — line thickness indicates connection strength. Click any node to explore.
Want to explore how this connects to concepts you choose? Try Nexus →